mitchell on demand estimator 5.7 install instructions

☑ A mixed effect proportional odds model was developed that adequately characterized the dose-response relationship. ☑ This crowdsourced clinical study aimed to characterize asparagus urinary odor perception kinetics and associated variability in healthy subjects. In addition, there is a need to educate more broadly on clinical pharmacology, pharmacokinetics, and clinical trials. Perceived urinary odor kinetics after consumption of asparagus spears has not previously been characterized. ☑ The consumption of asparagus is associated with the production and perception of malodorous urine with considerable variability. WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? This study design and tools can be used as a demonstration “crowdsourcing” project for studying population kinetics in organizational and educational settings. Age was found as the predictor of IIV in slope estimates. We estimated the half-life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose-response slope term with good precision (24.3%). A mixed effect proportional odds model was developed that adequately characterized the dose-response relationship. Eighty-seven subjects were included in the final analysis.

Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV).

Mitchell on demand estimator 5.7 install instructions